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GANT 58

CAS No. 64048-12-0

GANT 58( NSC 75503 | GANT58 | GANT-58 | NSC-75503 )

Catalog No. M15435 CAS No. 64048-12-0

GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 29 Get Quote
5MG 43 Get Quote
10MG 68 Get Quote
25MG 150 Get Quote
50MG 239 Get Quote
100MG 383 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
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Biological Information

  • Product Name
    GANT 58
  • Note
    Research use only, not for human use.
  • Brief Description
    GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM.
  • Description
    GANT 58 (NSC 75503) is a potent Gli antagonist and Hedgehog signaling (Hh) inhibitor that inhibits GLI1-induced transcription with IC50 of 5 uM; efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth in an in vivo xenograft model of human prostate cancer cells harboring downstream activation of the Hh pathway.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NSC 75503 | GANT58 | GANT-58 | NSC-75503
  • Pathway
    Wnt/Notch/Hedgehog
  • Target
    Gli
  • Recptor
    Gli
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    64048-12-0
  • Formula Weight
    392.47564
  • Molecular Formula
    C24H16N4S
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1(C2=CC=NC=C2)=C(C3=CC=NC=C3)C(C4=CC=NC=C4)=C(C5=CC=NC=C5)S1
  • Chemical Name
    Pyridine, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lauth M, et al. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60. 2. Hassounah NB, et al. Clin Cancer Res. 2012 May 1;18(9):2429-35.
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